There are two great antichristian religious systems of deceit revealed in the book of revelation. The "great western antichrist" of Roman Catholicism (Rev. 17 and 18) and the "great eastern antichrist" of Islam (Rev. 9). This has been the majority position of historic Protestant interpretation (Historicism) for centuries.
In this book Dr. Lee takes a look at the writings of John Calvin on this point.
"... both "Mahomet" and "the Pope" -- as we have already seen -- Dr. Calvin called "the two horns of Antichrist." Thus they correspond to the two legs of the later Roman Empire -- Islam and the Papacy."
In fact, when the classic historicist position is studied, the fulfillment in the case of Islam and Revelation chapter nine is seen to be so striking and well attested that "even advocates of other approaches who are adamant in their rejection of the historicist system of interpretation have admitted the convincing nature of this particular identification" (Steve Gregg, commenting on Rev. 9:1-6 in Revelation: Four Views, p. 176).
Also see Reformation CD 13-18, at the web link above (or at http://www.swrb.com/Puritan/reformation-bookshelf-cds.htm), for more on Islam in Bible prophecy.
Free MP3s by Dr. F.N. Lee, titled "Islam in the Bible," are on this site beginning at http://www.sermonaudio.com/sermoninfo.asp?sermonID=9130243446
Much more on "CALVIN on ISLAM in Revlation Chapter Nine" at: http://www.swrb.com/Puritan/calvin-on-islam.htm