The first command is to be fruitful and multiply and the second is to not eat of the fruit. The latter was violated eons ago. The prior is actively being violated by a majority of Christians for at least 50 years.
When you raise His ire, watch out. Wrath happens.
jpw wrote: that doesn't even include the ones we never know about taking the birth control pill, where the third mechanism comes into play. folks, looks like heaven's going to be full.